Testimonials from doctors
Dr G Cook
“I am used to drinking and smoking although I have greatly reduced the latter.I do feel that having tried Alcotox I just felt more energised and more normal.Good product.”
“I took 2 capsules after having some wine and did not have my usual headache and feeling of exhaustion”
Dr I Mian
“After a dinner with red wine I usually feel slightly under the weather.I took some Alcotox caps and felt perfect the next day”
Reviews by doctors
Dr. Ayesha Khan
New York University Medical Center for Dementia and Brain Aging
Alcohol consumption is responsible for hospitalizations due to complications that include systemic and end-organ damage to liver, stomach, esophagus oral cavity and other parts of gastrointestinal tract.
It is important to determine the patho-physiology of alcohol related organ damage. Alcohol is metabolized by the liver as part of the detoxification process and with the help of enzyme alcohol dehydrogenase, it is converted into the oxidized form of alcohol i.e. Acetaldehyde. Since liver cells have a limited capacity to neutralize acetaldehyde, moderate doses are leaked into blood stream before its elimination from the body.
Acetaldehyde is capable of shutting off cellular machinery, producing toxic metabolites and reactive oxygen species that damage cellular DNA and variety of other metabolic processes that leads to hepatic cirrhosis, liver cancer, oral cavity cancer, esophageal cancer, stomach cancer, pancreatitis and blindness.
Mode of functioning of Alcotox:
It is quite understandable that any remedy that aims at decreasing serum levels of acetaldehyde can prevent alcohol related organ or systemic damage. A commercial product like Alcotox can be considered a break-through in the prevention of alcohol related complications seen in individuals of all age groups.
Alcotox exerts its action by neutralizing the serum levels of Acetaldehyde that is beyond the detoxifying power of the liver cells. This is primarily because the liver cells are capable of oxidizing alcohol at an approximate rate of one standard drink per hour (this capacity may be slightly higher or slightly lower in different individuals based on the drug history and genetic factors).
With Alcotox, however consumers are able to eliminate a significant amount of acetaldehyde produced as a result of alcohol oxidation. The results were obtained by in-vitro trials conducted by an MHRA certified QC testing laboratory.
Role of Alcoholic Drinks in Liver Cirrhosis and the Preventive Role of Alcotox
Jose S. Castro, M.D.
Medical Towers Makati, Inc.
During my medical training , I had an unforgettable experience of attending to a 52 year-old male patient who had been suffering from liver cirrhosis. The said medical condition stemmed from several years of taking in alcoholic drinks. When he was admitted in the emergency room, the patient was very pale and the blood pressure was going down. Without doubt, there was bleeding somewhere.
In liver cirrhosis, the flow of blood from the intestines to the liver is obstructed. When this happens, there is elevated blood pressure in the hepatic portal vein, which transports blood from the intestines to the liver. Subsequently, bleeding could take place in the small blood vessels running in the inner lining of the esophagus.
In this patient, I assisted in the operation wherein we constructed a by-pass blood vessel which would ferry blood from the intestines into the large blood vessel, inferior vena cava, which returns blood into the heart. With the construction of the by-pass blood vessel, the blood would not pass through the liver, decompressing the elevated blood pressure in the hepatic portal vein. It was a 13-hour operation, physically draining and exasperating on our part! Yet, the procedure that we did was a temporizing measure, and not a definitive treatment of liver cirrhosis.
Every substance that is ingested will pass through the liver for metabolism. Consequently, the substance is either used by, or eliminated from, the body. When a substance is acted upon by the liver cells, by-products are formed called metabolites. In the case of alcohol, the main metabolite is acetaldehyde. When acetaldehyde combines with proteins in the liver, it damages the liver cells causing fat accumulation and fibrous tissue formation.
With the advent of Alcotox which successfully binds to acetaldehyde, there may now be hope for preventive measures against liver cirrhosis and other diseases attributable to alcohol intake.
ALCOTOX – A DOCTORS REVIEW
Dr. Ambreen Irfan
M.B;B.S, FCPS(1), MRCP(1),
PGR Radiology, Mayo Hospital Lahore.
‘Ethanol’ is the chemical name for Alcohol, and is a psychoactive recreational drug. Alcohol is responsible for the demise of at least 2.5 million people every year, and is the world’s third largest cause of disability and disease. It has been proven to be a basic causative factor in over 60 diseases, and a risk factor in a further 200 diseases.
Although the detrimental effects of Alcohol are acknowledged globally, it is widely consumed by people all over the world. Over 2 billion people consume alcohol according to the World Health Organization’s 2011 report Global Status Report on Alcohol and Health.
Alcotox may be able to shed some light on the preventive horizon of alcohol related health complications due to its ability to bind to, and neutralize Acetaldehyde. To understand how Alcotox works, we must first look at the metabolism of alcohol in the body.
METABOLISM OF ALCOHOL IN THE BODY
When we ingest Alcohol, it passes from the mouth to the stomach, from where it goes to the intestines. The intestines have blood channels that absorb the alcohol, and transport it to the liver, which is the main site for its metabolism.
In the liver, the Alcohol is degraded into acetaldehyde by the action of an enzyme known as alcohol dehydrogenase (ADH). Acetaldehyde is extremely toxic, and is immediately converted into acetic acid with the help of an enzyme known as aldehyde dehydrogenase 2 (ALDH2). Acetic acid is then converted into carbon dioxide and water, which are excreted from the body.
METABOLIC CAPACITY OF LIVER FOR ALCOHOL
The liver has a ‘Zero Order Reaction’ for the metabolism of alcohol. This means that the liver metabolizes alcohol into its last by-products immediately on ingestion, because the midway by product known as ‘acetaldehyde’ is a potentially lethal poison. The liver has a capacity to metabolize only 13 ml of alcohol in one hour, and any amount ingested beyond this level initiates ‘acetaldehyde poisoning’.
Most of the alcohol-induced diseases in the body are caused by alcohol’s by product acetaldehyde. Acetaldehyde is an extremely toxic chemical, and has a potential to bind with proteins, enzymes and neurotransmitters, through which it exerts its injurious effects.
A few harmful effects of acetaldehyde are given below.
- Acetaldehyde binds with the DNA of the hepatocytes to form DNA adducts such as 1,N2-propanodeoxyguanosine which leads to an impaired protein secretion from the liver, leading to hepatomegaly (enlargement of the liver).
- Acetaldehyde binds with proteins of the hepatic cell membranes, leading to the formation of adducts, which are not recognized by the immune system of the body, and thus a reaction is initiated against the altered cells, leading to hepatic damage, manifested as cirrhosis of the liver. The same damage may also occur in the pancreas, leading to pancreatitis.
- Binding of acetaldehyde with DNA of different cells leads to genetic mutations, resulting in cancerous cells. These are manifested as Oral, breast, hepatic and pancreatic cancers.
- Acetaldehyde can form adducts by interacting with neurotransmitters in the brain like serotonin and dopamine, leading to the problems of hangover and dependence on alcohol.
- Acetaldehyde causes severe damage to the mitochondrial membranes in the liver where the metabolism of acetaldehyde takes place. As a result, chronic alcohol consumption leads to a vicious cycle of lesser tolerance to alcohol as more and more acetaldehyde is produced with a lesser rate of metabolism.
- Acetaldehyde is potentially fetotoxic, and causes damage to the embryonic neural crest cells, and produces gross abnormalities in the fetus.
ALCOTOX- DEFENSE AGAINST ACETALDEHYDE POISONING
Alcotox has been designed after years of research to target acetaldehyde, the main culprit behind alcohol-induced diseases. Alcotox has been established to eliminate 86% of the acetaldehyde produced by a glass of 12.5% proof white wine. This discovery may be the foundation for the avoidance of an estimated 210,000 deaths in the next two decades in the UK alone, an estimate established by the Royal College of Physicians.
Alcotox is a neutraceutical product containing vitamins and amino acids, which are known mediators of the enzymatic reactions involved in acetaldehyde metabolism. In addition, it also increases the anti oxidant capacity of the body by providing the three precursors of glutathione, Glycine, Glutamate and Cysteine. Glutathione is an important enzyme in the body that prevents the oxidative damage caused by alcohol metabolites.
Alcotox may also prove to be of benefit to people of oriental descent, who are genetically deficient in the enzyme aldehyde dehydrogenase, and thus accumulate large quantities of acetaldehyde in their body on alcohol consumption. Alcotox provides their body with the capability of metabolizing the toxic acetaldehyde, thus preventing the occurrence of the ‘Asian flush’.
Alcotox may revolutionize the concept of alcohol induced diseases, as it promotes the degradation of the perpetrator behind the damage; Acetaldehyde. The future may see Alcotox as a routine supplement for people who consume alcohol, and may prove to be their savior.